Table 2. Comparison of THC Potency in FAAH−/− vs FAAH+/+ Mice That Were Naive or Treated Repeatedly with THC, and FAAH−/− Mice Treated Repeatedly with AEA.
| Subchronic treatment |
Antinociception |
Catalepsy |
Hypothermia |
|||
|---|---|---|---|---|---|---|
| −/− | +/+ | −/− | +/+ | −/− | +/+ | |
| Naive | 22 (17–30) | 19 (14–26) | 21 (15–28) | 18 (13–25) | 22 (16–32) | 18 (15–22) |
| THC | 25±4%MPE @ 300 mg/kg | 44±16%MPE @ 300 mg/kg | 67% @ 300 mg/kg | 62% @ 300 mg/kg | 224 (190–266) | 109 (62–190) |
| AEA | 42±8%MPE @ 300 mg/kg | n.d. | 25% @ 300 mg/kg | n.d. | 133 (106–166) | n.d. |
Data represent ED50 values (95% CI) or maximum effect±SEM if efficacy<70% (n.d.=not determined) and are represented in mg/kg.