Table 5. [3H]WIN55,212-2 Binding in Brain Sections from Vehicle-, THC-, and AEA-Treated FAAH−/− Mice.
Region | Vehicle | THC | Anandamide |
---|---|---|---|
Caudate putamen | 1.3±0.13 | 0.82±0.11* | 0.95±0.09 |
Globus pallidus | 2.69±0.28 | 1.55±0.12* | 2.31±0.18 |
Hippocampus | 1.08±0.10 | 0.49±0.07* | 0.88±0.06 |
Substantia nigra | 3.61±0.44 | 2.25±0.20* | 3.11±0.29 |
PAG | 0.76±0.10 | 0.43±0.07* | 0.57±0.06 |
Cerebellum | 1.79±0.16 | 1.19±0.12* | 1.69±0.18 |
Brain sections were assayed as described in Materials and Methods. Data shown are mean specific [3H]WIN55,212-2-binding values (pCi/g)±SEM from 8 to 12 mice per group (*p<0.05 vs vehicle-treated animals, one-way ANOVA with a post hoc Dunnett's test).