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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Microcirculation. 2009 Oct;16(7):629–639. doi: 10.1080/10739680903131510

Figure 5.

Figure 5

A representative recording of cortical blood flow (CoBF) and direct current (DC) potential and NMDA-evoked dose-dependent cortical blood flow (CoBF) increases in newborn pigs. Right panel: NMDA (10−3 M) application onto the cortex elicited a transient CoBF increase (CoBF 1) and a prolonged DC potential deflection; however, propagation of the CoBF response was not detected with the distant probe (CoBF 2). On the time axis, the 0 time point indicates the beginning of drug application onto the brain surface. The stimulus was removed 10 minutes later, when the window was flushed with artificial cerebrospinal fluid. Left panel: Average CoBF change per minute was calculated during a 10-minute period of drug application. Bars represent the maximal CoBF changes within the examined time interval. Artificial cerebrospinal fluid did not produce significant CoBF changes, while topical NMDA (10−4 and 10−3 M) increased CoBF in a concentration-dependent manner. Data are mean±standard error of the mean (n=5; *P < 0.05) via one-way repeated measures analysis of variance and Tukey’s test.