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. Author manuscript; available in PMC: 2011 Jun 24.
Published in final edited form as: J Med Chem. 2010 Jun 24;53(12):4585–4602. doi: 10.1021/jm100054f

Figure 2. Roles of Hsp70 in anti-apoptotic signaling.

Figure 2

Hsp70 is thought to promote survival and block apoptosis through interactions with multiple steps in the pathway. For some substrates, Hsp70’s role appears to be stabilization of the substrate, while it appears to mediate the degradation of other substrates. The regulatory mechanisms that govern these activities are not known. See the main text and Table 1 for references.