. Author manuscript; available in PMC: 2011 Jun 24.

Published in final edited form as: J Med Chem. 2010 Jun 24;53(12):4585–4602. doi: 10.1021/jm100054f

Table 1.

Roles of Hsp70 in Apoptotic Signaling

Process	Role of Hsp70	Ref.
Caspase-Dependent
Pathway
Bid	Hsp72 inhibits TNF activation of the Bid pathway	54
Caspase-9	Hsp70 inhibits recruitment of procaspase-9 to the apoptosome	58
	Hsp70 binds to Apaf-1, preventing formation of the active apoptosome	194
BCL2	Hsp70 inhibits the proteasomal degradation of Bcl2 proteins	53
	Hsp70 inhibits cytochrome c release from mitochondria by inhibiting Bad and Bax	195
Caspase-3	Hsp70 inhibits caspase-3 induced apoptosis	195
Caspase-Independent
Pathway
JNK	Hsp72 inhibits JNK induced apoptosis, but its ATPase activity is dispensable	61, 196–200
AIF	Hsp70 prevents the release of AIF from mitochondria	64, 201, 202
Lysosome	Hsp70 stabilizes lysosomal membrane integrity	59, 203, 204
p53	Hsp70 blocks p53-induced senescence through PI3K	⁴⁶, ⁶⁰, ²⁰⁵– ²⁰⁷