Figure 2.

Probability of staying free of (A) cancer and (B) compound phenotype of myocardial infarction (MI) and intermittent claudication (IC) for (A) men and women and (B) men carrying compound genotypes of the ADRB2 Arg¹⁶Gly and Gln²⁷Glu polymorphisms (patterns of probability are ordered according to increasing relative risks; see insets). Protective Gly¹⁶Glu²⁷ haplotype is italicized and underlined (given that the Arg¹⁶Glu²⁷ haplotype is virtually lacking, see Table 1, haplotypes are uniquely determined from the respective genotypes). The letter “N” in the inset denotes sample size with non-missing information on all covariates. The numbers in parentheses are counts of individuals with onsets of respective condition within the follow-up period (months). The RR (CI) denotes relative risks (confidence intervals) calculated using the Cox regression model adjusted for age, sex (when necessary), systolic and diastolic blood pressures, total and high density lipoprotein cholesterol, body mass index, smoking, and diabetes. ^*0.01<p<=0.05; ^**p<=0.01.