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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: J Immunol. 2009 Dec 11;184(2):1031–1040. doi: 10.4049/jimmunol.0902773

FIGURE 6.

FIGURE 6

Perforin is required for upregulation of VEGF expression during CD8 T cell-mediated CNS vascular permeability. At 24 h post-administration of (A) mock E7 control peptide or (B) VP2121–130 peptide, C57BL/6 perforin-deficient mouse brains were analyzed for VEGF mRNA using in situ hybridization and VEGF protein using Western blot analysis (n = 4 animals for each analysis). C, VEGF mRNA in the SG of the hippocampal dentate gyrus and (D) VEGF protein levels in the whole brain reveal no changes in VEGF expression in perforin-deficient mice consistent with this strain being resistant to CNS vascular permeability.