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. Author manuscript; available in PMC: 2010 Jul 2.
Published in final edited form as: J Cell Physiol. 2009 Jan;218(1):157–166. doi: 10.1002/jcp.21581

Fig. 9.

Fig. 9

A: Effect of pretreatment with caspase-3 and p38-MAPK inhibitors on superoxide-induced death of RA-treated aHSCs. aHSCs were incubated in the presence of 2.5 µM 13-cis-RA for 5 days, washed and incubated with 10 µM DEVD-fmk or SB203580 for 30 min prior to the addition of 1 mM HX (Control) ± 2 mU/ml XO (Superoxide). MTT assay was performed at 24 h. *P< 0.05 versus RA; **P<0.01 versus control. B: Effect of RA on superoxide-induced changes in GSH and antioxidant enzymes in aHSCs. aHSCs were incubated in the presence of 2.5 µM 13-cis-RA for 5 days, washed and stimulated with 1 mM HX ± 2 mU/ml XO for 24 h, after which various assays were performed.*P<0.05 versus RA+HX and <0.001 versus HX;**P<0.01 versus HX.