Table 1.

The attenuation of age-associated diseases by polyphenols

Polyphenol	Effect	Result
Resveratrol	activation of SIRT1 leading to deacetylation of p53, NF-κB, HSF-1, FOXO1/3/4, and PGC-1α	influences replicative senescence, inflammation, apoptosis, stress resistance, and metabolism
	activation of SIRT1 may mimic calorie restriction	increased lifespan
	binds receptors in the brain to stimulate production of transthyretin (TTR)	TTR sequesters Aβ fibrils important in etiology of Alzheimer’s disease
EGCG	upregulates NO production in endothelial cells	may prevent inflammation associated with atherosclerosis
	down-regulates cGMP and NO production in carcinoma cells	prevention of metastasis
	blocks EGF receptor in cervical cancer cells	prevention of tumor growth
Quercetin	down-regulates production of TNF-α	anti-inflammatory properties reduce development of atherosclerosis