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. Author manuscript; available in PMC: 2010 Jul 2.
Published in final edited form as: J Med Chem. 2005 Apr 7;48(7):2361–2370. doi: 10.1021/jm0491703

Figure 5.

Figure 5

The regions of the binding site responsible for specific interactions of probes with TACE. The 24 major rows correspond to individual MMPs. Each major row is split into three additional rows according to difference level: 90, 80, and 70% (top to bottom). The major columns correspond to specific parts of the binding site (Figure 2). Each major column is split into six columns showing the preference for probe types by TACE or MMP: negative probe preferred by TACE (blue box) or by particular MMP (cyan box), neutral probe preferred by TACE (green box) or by particular MMP (yellow box), positively charged probe preferred by TACE (magenta box) or by particular MMP (red box).