Figure 2.

Benchmarking the walking strategy. The plots show the distribution of AUC values for single-domain queries in scop 1.75. AUC, where coverage is TP/T and reliability is TP/P with T the number of members of a scop class, P number of matches above a given Z-score, and TP the number of members of a scop class above a given Z-score. Evaluated classes are scop folds (thin line), scop superfamilies (medium thick line) and scop families (thick line). Classes with fewer than 10 or more than 500 members are excluded. Query structures consisted of single domains from scop classes a-d, filtered at 90% sequence identity. Matches to all PDB structures which contained an instance of a domain in scop classes a-d were included in the evaluation.