A, PL5, MIA PaCa-2 and PANC-1 cells were treated with K1 50 µM, Sorafenib 2.5 µM or K1 plus Sorafenib and the cell number was estimated by a DNA fluorometric assay. B. PL5 cells were treated separately with 50 µM K1, 25 µM K2, 10 µM K5, 2.5 µM Sorafenib or combination Sorafenib with Ks. Cell number was counted on day 3. Each experiment was run in triplet, repeated three times and expressed mean SD. P value is determined by student’s t test.