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. 2010 Jun 2;30(22):7495–7506. doi: 10.1523/JNEUROSCI.0470-10.2010

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Copyright © 2010 the authors 0270-6474/10/307495-12$15.00/0

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Figure 9. — Model of LRRTM, neurexin, and neuroligin interactions at a glutamate synapse. Diagram of a glutamate synapse containing the major postsynaptic LRRTMs (LRRTM1 and LRRTM2) and neuroligin (NLG1+B), and presynaptic neurexins. β-Neurexins(−S4) bind either LRRTMs or NLG1(+B), β-neurexins(+S4) bind only NLG1(+B), and α-neurexins(−S4) bind only LRRTMs. It is not clear whether α-neurexins(+S4) (not shown) are also present; these bind neither LRRTMs nor NLG1(+B). α-Neurexins are necessary to recruit presynaptic calcium channels. LRRTMs and NLG1 bind PSD-95 and related MAGUK scaffolds via different PDZ (PSD-95/Discs large/zona occludens-1) domains.