Skip to main content
. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Prostaglandins Leukot Essent Fatty Acids. 2010 Mar 15;82(4-6):327–332. doi: 10.1016/j.plefa.2010.02.003

Figure 3. Protectin D1/neuroprotectin PD1 biosynthesis.

Figure 3

(A) DHA is converted by ALOX15 to the pivotal intermediate 17S-H(p)DHA that serves as a substrate for further enzymatic transformation to PD1/NPD1 via a 16(17) epoxide intermediate. This route of synthesis is distinct from the formation of the double dioxygenation product that does not share the same bioactions as PD1/NPD1. (B) Lipid extracts were obtained from inflamed murine lung and taken to LC-MS/MS that uncovered PD1/NPD1. Mass spectra revealing the characteristic fragmentation ions for PD1/NPD1.