Table 2.

Incremental Cost-Effectiveness Ratios (ICERs) for Neonatal Staphylococcus aureus (S. aureus) Vaccination

	All Staphylococcus. aureus Model
Cost of Vaccine	S. aureus Attack Rate (AR)	Vaccine Efficacy
		0.1	0.25	0.5	0.75	0.9
$100
	0.1%	71,609	33,293	15,406	8,405	78,99
	1%	6,252	2,450	996	566	364
	2%	3,182	1,031	299	47	***
	5%	956	138	***	***	***
	10%	292	***	***	***	***
$200
	0.1%	128,392	48,743	25,668	21,873	16,753
	1%	13,321	5,522	2,625	1,514	1,187
	2%	6,715	2,542	1,064	542	376
	5%	2,520	716	150	***	***
	10%	1,041	137	***	***	***
$300
	0.1%	175,146	84,725	38,733	29,151	23,423
	1%	23,178	7,756	4,025	2,545	1,959
	2%	10,214	3,959	1,819	987	785
	5%	4,056	1,382	434	149	47
	10%	1,782	420	***	***	***
$500
	0.1%	320,971	176,788	63,407	50,172	47,581
	1%	39,368	14,358	6,892	4,384	3,636
	2%	17,842	6,879	3,053	1,882	1,672
	5%	6,878	2,388	1,030	522	377
	10%	3,284	1,034	285	58	***
$1,000
	0.1%	813,431	28,3074	143,605	96,925	81,078
	1	65,770	27,265	13,885	9,117	7,611
	2%	37,497	14,347	6,673	4,678	3,601
	5%	13,064	5,539	2,448	1,514	1,197
	10%	6,668	2,492	1,015	544	359
	Methicillin Resistant Staphylococcus aureus (MRSA) –specific Model
Cost of Vaccine	MRSA Attack Rate (AR)	Vaccine Efficacy
		0.1	0.25	0.5	0.75	0.9
$100
	0.1%	113,220	33,489	13,317	9,110	6,745
	1%	5,564	2,213	861	470	334
	2%	3,122	889	308	72	5
	5%	912	173	***	***	***
	10%	252	***	***	***	***
$200
	0.1%	622,854	33,580	25,443	16,698	14,459
	1%	10,251	5,166	2,014	1,287	1,062
	2%	6,397	1,926	973	497	324
	5%	4,230	711	158	***	***
	10%	851	138	***	***	***
$300
	0.1%	152,563	207,014	54,506	23,525	20,621
	1%	26,561	7,974	3,478	2,187	1,783
	2%	8,232	4,414	1,454	931	703
	5%	3,210	1,296	379	153	69
	10%	1,617	431	22	***	***
$500
	0.1%	492,442	97,543	56,458	48,635	32,205
	1%	25,355	12,792	6,244	3,813	3,273
	2%	16,960	5,924	2,764	1,689	1,475
	5%	5,404	2,151	944	478	349
	10%	2,578	910	268	62	2
$1,000
	0.1%	503,609	273,739	195,166	87,632	73,933
	1%	88,168	24,679	12,854	8,391	6,628
	2%	31,983	11,657	6,264	3,741	3,115
	5%	12,949	4,826	2,059	1,383	1,029
	10%	5,521	2359	975	482	346

Values shaded in light grey are cost-effective (≤$50,000/QALY)

Values shaded in dark grey with *** indicate that vaccination is the dominant strategy