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NHC-catalyzed cyclization-lactonization of substrate 34.
 | |||
|---|---|---|---|
| Entry | Catalyst | Yielda | d.r. (desired:undesired) |
| 1 | IMesCl | 75% | 1:3 |
| 2 | 29 | 84% | 1:1.2 |
| 3 | ent-29 | 88% | 1:1.1 |
| 4 | 12 | 93% | 1:1.7 |
| 5 | 31 | 77% | 1:1.5 |
All reactions listed proceeded with 100% conversion.
Combined isolated yield of both diastereomers.
