Figure 1.

Fold-change detection means that the dynamics of the output (amplitude and duration of the transcription of gene Z) depends only on the fold-changes in the level of the input signal, not on the absolute levels of the input signal.

Fold-change detection means that the dynamics of the output (amplitude and duration of the transcription of gene Z) depends only on the fold-changes in the level of the input signal, not on the absolute levels of the input signal.