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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Nat Rev Microbiol. 2010 May 4;8(6):423–435. doi: 10.1038/nrmicro2333

Figure 3. Aminoglycoside triggers for radical-mediated cell death.

Figure 3

The interaction between the aminglycoside and ribosome causes mistranslation and misfolding of membrane proteins. Incorporation of mistranslated, misfolded proteins into the cell membrane stimulates the envelope (Cpx) and redox-responsive (Arc) two-component systems. Activation of these systems perturbs cellular metabolism and the membrane potential (DY), resulting in the formation of lethal hydroxyl radicals. (Modified with permission from ref 10)