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Heat shock factor-1 (HSF1) knock-out mice have increased severity of pancreatitis. In the absence of caerulein administration, HSF1 knock-out mice (B) demonstrate similar pancreatic morphology as wild-type mice (A). HSF1 knock-out mice (D) demonstrate increased severity of pancreatitis in response to caerulein administration as compared to HSF1 wild-type mice (C).
