Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Localisation of P49 on N-terminus and P389 on C-terminus. β1AR activation results via G protein (Gs) and adenylate cyclase (AC) pathway in increase of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA). PKA induced phosphorylation inactivates INa channel activity. Flecainide inhibits INa directly.
