Direct co-culture of a small number of rat UCMSCs significantly attenuated the growth of PAN02 cells. Rat UCMSCs (500 and1000 cells/well) were co-cultured with 3 × 103 PAN02 (rUCMSC: PAN02 ratio, 1:6 and1:3). After three days of co-culture, the MTT assay was carried out. Pictures show the morphology of PAN02 alone or PAN02 co-cultured with rat UCMSCs for 72 hrs. Histogram shows the summarized results from the MTT assay. The experiment was performed twice with 6 determinations at each point. Results are presented as the mean ± standard error of mean. The ns indicates not significant. *, p≤0.05, **, p<0.001 as compared to the level of control.