Figure 4.

Coronal sections showing intracortical axonal connections in the right RFA originating from the ipsilateral CFA. In normal rats, few axons were detected in the cortex at the RFA level with BDA injection into the cortex of the CFA (A). Biotinylated dextran amine-positive axons were increased in the ischemic animals treated with PBS (B) and BMSCs (C). Quantitative data showed a significant enhancing effect on both MCAo lesion and BMSC treatment, respectively (D). Insets in A, schematic drawing of the rat brain dorsal view showing the RFA region from which slices were obtained (lines) and BDA-injection position in the CFA (dot). Cross-hatching indicates the ischemic lesion. Scale bar=250 μm.