Table 1.
Differential Gene Expression in Atoh1-induced versus Gli-induced tumors
Gene Name | Gene Symbol | Fold Change |
Gene Function |
---|---|---|---|
Differentiation, Migration, Adhesion: | |||
S100 protein | S100b | − 8.3 | Regulation of neuronal synaptic plasticity |
Id4 | Id4 | − 5.6 | Inhibitor of DNA binding |
Contactin 2 | Cntn2, Tag1 | − 4.5 | Cell adhesion, neuronal migration |
Ephrin B2 | Efnb2 | − 4.3 | Cell differentiation, migration |
L1cam | L1cam | − 3.8 | Adhesion molecule, regulates migration, neurite formation |
Nrcam | Nrcam | − 2.5 | Surface protein, regulates neurite outgrowth |
Cdk5 | Cdk5r1, p35 | − 2.5 | Kinase, regulates migration |
Doublecortin | Dcx | − 2.4 | Microtubule binding, regulates migration |
Plexin B2 | Plxnb2 | − 2.4 | Positive regulation of axon formation |
Cadherin 4 | Cdh4 | + 4.4 | Cell adhesion |
Semaphorin 4d | Sem4d | + 2.7 | Cell differentiation and migration |
Cell Proliferation: | |||
Kit Ligand | Kitl | − 4.2 | Transient amplifying cell self-renewal |
Cyclin D1 | Ccnd1 | − 0.87 | G1 cyclin |
Cyclin D2 | Ccnd2 | −1.7 | G1 cyclin |
Cyclin A2 | Ccna2 | +1.1. | G1/S cyclin |
Cyclin B1 | Ccnb1 | +1.1 | G2/M cyclin |
Cyclin B2 | Ccnb2 | +1.1 | G2/M cyclin |
Cell division cycle 25 homolog C |
Cdc25c | +1.1 | Phosphatase, regulates mitotic entry |
Polo-like kinase 1 | Plk1 | +1.2 | Kinase, regulates cell cycle checkpoints |
Aurora kinase A | Aurka, Ark1, Stk6 | −1.1 | Kinase, regulates spindle formation |
N-Myc | Mycn | +1.1 | Transcription factor |
p21, Waf1, Cip1 | Cdkn1a | −1.5 | CDK inhibitor |
p57Kip2 | Cdkn1c | −3.0 | CDK inhibitor |