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. Author manuscript; available in PMC: 2010 Jul 3.
Published in final edited form as: Curr Diabetes Rev. 2008 Nov;4(4):329–339. doi: 10.2174/157339908786241179

Table 4.

Characteristics of family-based association tests of parent-of-origin effects.

Model Characteristics CPG1 CEPG2 Combined
LRT3 		Log-linear
models4 		MFG5 PO-LRT6 QPL7
Child genotype risk
effect		 X X X X X X
Maternal genotype risk
effect		 X X X X X X
Maternal-child genotype
risk effect		 X X X X X X
POE effect X X X X X X
Quantitative trait X
Dichotomous trait X X X X X X
Handles multi-allelic
markers, multiple
markers		 X X
Excludes ambiguous
(1,1,1) triads		 X X
Handles missing
parental data		 X X X X
Uses unaffected siblings X X
References Cordell
et al .
2004
[78]		 Cordell et
al. 2004
[79]		 Rampersaud et
al. 2007 [80]		 Weinberg et al.
1998 [81]		 Shinsheimer et
al. 2003 [60]		 Weinberg et
al 1998 [82]		 Kistner
et al.
2006
[83]
1

CPG-Conditional on parental genotypes;

2

CEPG -Conditional on exchangeable parental genotypes;

3

Combined likelihood ratio test;

4

Log-linear model;

5

MFG- Maternal-fetal incompatibility test;

6

PO-LRT - Parent of origin likelihood ratio test;

7

Quantitative polytomous logistic model.