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. 2010 Mar 1;38(12):3880–3890. doi: 10.1093/nar/gkq126

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — (A) Methylation patterns of seven neighboring CpG sites in the APC promoter region in adult blood (n = 26), adult cortex (n = 12), cultured (n = 12) and native (n = 29) CVS from first trimester abortions, and sperm (n = 45) samples. The box plots display the distribution of methylation values at each CpG site. Please note the different graduations of scale on the y-axis. (B) PAM analysis of methylation patterns across the seven CpGs. Each sample is represented by one column. PAM uses cross-validation to calculate posterior class probabilities for each sample. A classifier which is based upon this would vote for the class with the highest posterior in a given sample. Native CVS and sperm samples would be classified correctly to a large extent, whereas almost all other samples would be misclassified as sperm.