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. 2010 Apr 14;38(12):e131. doi: 10.1093/nar/gkq224

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Evaluation of the reweighting scheme. (a and b) Unadjusted and re-weighted base-level counts for reads from the WT experiment mapped to the sense strand of a 1-kb coding region in S. cerevisiae (YOL086C). The graey bars near the x-axis indicate unmappable genomic locations. (c) The goodness-of-fit statistics based on unadjusted and reweighted counts for 552 highly expressed regions of constant expression. (d) Smoothed histograms of the reduction in goodness-of-fit statistics when using the re-weighting scheme, evaluated in five different experiments. Values greater than zero indicate that the re-weighting scheme improves the uniformity of the read distribution.

Inline graphic — Evaluation of the reweighting scheme. (a and b) Unadjusted and re-weighted base-level counts for reads from the WT experiment mapped to the sense strand of a 1-kb coding region in S. cerevisiae (YOL086C). The graey bars near the x-axis indicate unmappable genomic locations. (c) The goodness-of-fit statistics based on unadjusted and reweighted counts for 552 highly expressed regions of constant expression. (d) Smoothed histograms of the reduction in goodness-of-fit statistics when using the re-weighting scheme, evaluated in five different experiments. Values greater than zero indicate that the re-weighting scheme improves the uniformity of the read distribution.