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4-OHEN produces five times more 4-OHEN–DNA adducts than does 4-OHEQ. MCF-7 cells were exposed to either 4-OHEN or 4-OHEQ in various concentrations for 3 h. The induction of 4-OHEN–DNA adducts was then quantified using the sensitive direct ELISA as shown in Figure 5. Each point shows the mean (±SD) of three independent experiments.
