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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Cancer Res. 2010 Jun 1;70(13):5549–5557. doi: 10.1158/0008-5472.CAN-09-4254

Figure 4. Characterisation of tumors induced by G12VKRAS.

Figure 4

A. A deep area from a perianal melanocytic lesion predominantly composed of hypo/amelanotic spindle cells exhibiting conspicuous nuclear pleomorphism and large nucleoli (arrowheads).

B. A deep area from a perianal melanocytic lesions composed of a mixture of spindle and epithelioid cells displaying the presence of pigmented cells. The arrow highlights an example of a nuclear pseudo-inclusion.

C. Ki67 positive staining within the deeper aspects of the neoplastic lesion.

D. Photomicrographs of mitotic figures (arrows) found within the deeper aspects of a perianal lesion.