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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Clin Cancer Res. 2010 Jun 22;16(13):3368–3377. doi: 10.1158/1078-0432.CCR-10-0438

Figure 6. Glioblastoma “core signalling pathways” are dysregulated by copy number changes less frequently in paediatric than adult tumours.

Figure 6

Signalling pathway heatmap of interactions defined by the TCGA (1). Genes with amplifications are shown in red, genes with focal deletion are shown in blue. The overall frequency of copy number alteration in paediatric high grade glioma for each pathway is listed, and is significantly lower than in adults (25% RTK/PI3K, 19% p53 and 22% RB versus 59%, 70% and 66% for adult glioblastoma respectively).