Fig. 4. ZIP4 increases the expression of MMP-2 and MMP-9.
The mRNA level for MMP-2 and MMP-9 were analyzed by real time PCR. Relative mRNA level is presented as fold change compared with the vector control. A. Relative MMP-2 mRNA level in MIA-V and MIA-ZIP4 subcutaneous xenografts. B. Relative MMP-2 mRNA level in MIA-V and MIA-ZIP4 orthotopic xenografts. C. Relative MMP-9 mRNA level in MIA-V and MIA-ZIP4 subcutaneous xenografts. D. Relative MMP-9 mRNA level in MIA-V and MIA-ZIP4 orthotopic xenografts. All data shown are the mean±SD of three separate experiments. *p < 0.05.