Table 2.
Patient characteristic | All patients | SAB | Low dose ICS | Medium dose ICS ± LAB | High dose ICS ± LAB ± OS |
---|---|---|---|---|---|
Number of patients | 108,455 | 29,740 | 9,384 | 37,125 | 32,206 |
Mean ag e ± SD at start of follow-up | 72.7 ± 7.0 | 74.7 ± 7.6 | 72.7 ± 6.8 | 71.4 ± 6.4 | 72.3 ± 6.7 |
% Female patients | 53.1 | 54.0 | 56.3 | 53.3 | 51.0 |
% Indigenous patients | 0.6 | 0.8 | 0.4 | 0.5 | 0.6 |
Mean ± SD GP visit numbera | 30.2 ± 23.7 | 26.7 ± 22.3 | 28.8 ± 22.1 | 29.3 ± 22.1 | 34.9 ± 26.4 |
Median GP visit regularity a,b | 45.1 | 29.0 | 43.2 | 46.0 | 62.2 |
All-cause mortality analyses | |||||
Number of patients included in analysesc | 66,390 | 14,159 | 5,985 | 23,849 | 22,397 |
Average years ± SD of follow-up | 4.8 ± 3.2 | 4.2 ± 2.9 | 4.9 ± 3.3 | 4.6 ± 3.1 | 5.4 ± 3.3 |
Person-years of follow-up | 319,138.2 | 59,641.7 | 29,285.3 | 109,150.4 | 121,060.8 |
Number of deaths at the end of follow-up | 4,841 | 827 | 369 | 1,301 | 2,344 |
Mortality rate (per 100,000 PY) | 1,516.9 | 1,386.6 | 1,260.0 | 1,191.9 | 1,936.2 |
First CRD hospitalisation analyses | |||||
Number of patients included in analysesd | 54,641 | 12,826 | 5,434 | 20,113 | 16,268 |
Average± SD years of follow-up | 4.4 ± 3.1 | 4.2 ± 2.9 | 4.8 ± 3.3 | 4.1 ± 3.0 | 4.6 ± 3.2 |
Person-years of follow-up | 237,839.6 | 54,101.4 | 25,924.6 | 83,435.4 | 74,378.3 |
Number of first hospitalisations at the end of follow-up | 7,331 | 447 | 330 | 2,400 | 4,154 |
Hospitalisation rate (per 100,000 PY) | 3,082.3 | 826.2 | 1272.9 | 2876.5 | 5585.0 |
aDuring the 3-year exposure period
bMultiplied by 100,000
cPatients who were alive at the end of the exposure and wash-out periods
dPatients who did not have a CRD hospitalisation during the exposure and wash-out periods and who were alive at the end of the two periods
SAB = short-acting bronchodilators
ICS = inhaled corticosteroids
LAB = long-acting bronchodilators
OS = oral steriods
PY = person-years