Table 1.
Biomarkers for pertussis vaccine toxicity.
| Category | Accession no. | Symbol | Brief description |
|---|---|---|---|
| Inflammation | NM_053587 | S100A9 | A calcium binding protein that may be associated with acute inflammatory processes, coupled with S100a8 |
| NM_053822 | S100A8 | May play a role in inflammatory responses such as cell motility, coupled with S100a9 | |
| NM_019323 | MCPT9 | A serine protease expressed in mast cells, but the precise function has not yet been determined | |
| NM_031530 | CCL2 | A ligand for CCR2 that acts as a chemoattractant of monocytes | |
| IFN inducible, immune response | NM_001033691 | IRF7 | Unknown |
| NM_134350 | MX2 | Involved in inhibiting vesicular stomatitis virus | |
| NM_203410 | IFI27 | Induced by steroid hormone, IFN, and LPS in endometrium at implantation, dendric cells, and macrophases | |
| NM_001007694 | IFIT3 | May induced by IFN or virus infection | |
| Y07704 | BEST5 | Induced by IFN and involved in bone formation | |
| Peptidoglycan metabolism | NM_031055 | MMP9 | Metalloproteinase involved in extracellular matrix remodeling, bone resorption, and immune responses |
| NM_022221 | MMP8 | May play a role in appositional bone formation and regulation of the extracellular matrix | |
| Xenobiotic metabolism | J02627 | CYP2E1 | Protects hepatocytes from stress-induced cell death |
| Others | NM_001106862 | NGP | Unknown |