Table 4.
Overview of the scores used to rank the putative GRB2 interactors. NCBI protein accession number, Score1, Score2, the sequence and the structure configuration of the best motif, Score3 and Score4, were reported. The last column showed the final score assigned to each interactor.
| Access number | Score1 | Score2 | Best motif of sequence | Best struct. motif | Score3 | Number int. sites | Score4 | Final score |
|---|---|---|---|---|---|---|---|---|
| NP_001306 | 344.7 | 2378 | PPP[IVL] | LLLL | 148.1 | 27 | 181.2 | 2.52 |
| NP_003014 | 4 | 2177 | PPP[IVL] | LLLL | 95 | 12 | 168 | 2.33 |
| NP_060910 | −11.3 | 1774 | PPP[IVL]P | LLLLL | 2469.1 | 18 | 8.9 | 2.21 |
| NP_004432 | 1688.3 | 3910 | [ED]D[ED] | LLL | 2 | 31 | 14.5 | 2.08 |
| NP_004407 | −43.3 | 2468 | PPP[IVL] | LLLL | 86 | 22 | 92.2 | 2.02 |
| NP_003713 | −40.3 | 2417 | PPP[IVL] | LLLL | 78.4 | 24 | 87 | 1.99 |
| NP_005145 | −52.3 | 3370 | [ED]N[IVL] | LLL | 1.2 | 34 | 15.1 | 1.98 |
| NP_002030 | −2.3 | 2269 | PPP[IVL] | LLLL | 76.8 | 21 | 83.3 | 1.95 |
| NP_002511 | −3.7 | 1220 | [ED]ED[ED] | LLLL | 136 | 20 | 151.8 | 1.9 |
| NP_005148 | 29.3 | 3261 | [ED]N[IVL] | LLL | 1.2 | 24 | 4.9 | 1.88 |
| NP_003311 | −25 | 2204 | [ED]ED[ED] | LLLL | 71.3 | 26 | 81.6 | 1.86 |
| NP_003362 | 1032.3 | 3399 | [ED]D[ED] | LLL | 2.4 | 24 | 7 | 1.86 |
| NP_006566 | 798 | 3359 | [ED]D[ED] | LLL | 2.4 | 27 | 9.9 | 1.84 |
| NP_149129 | −24.7 | 3141 | [HQN][KR]S[GTSWYP][GTSWYP] | HLLLL | 18.7 | 11 | 20.1 | 1.82 |
| NP_005556 | 93.7 | 2141 | [ED]ED[ED] | LLLL | 75 | 12 | 77 | 1.8 |
| NP_036252 | 11.3 | 2472 | PPP[IVL] | LLLL | 83.5 | 26 | 94.1 | 1.76 |
| NP_003806 | 516.3 | 3112 | [IVL]N[IVL] | LLL | 1 | 22 | 8.3 | 1.76 |
| NP_001973 | 955.7 | 1960 | [ED]ED[ED] | LLLL | 29.8 | 31 | 40.6 | 1.75 |
| NP_004439 | 1297.3 | 2468 | [ED]D[ED] | LLL | 1.6 | 32 | 11.7 | 1.73 |
| NP_612401 | −50.3 | 2223 | PPP[IVL] | LLLL | 75.4 | 11 | 77 | 1.73 |
| NP_542179 | −19.3 | 2370 | PPP[IVL] | LLLL | 91 | 27 | 103.9 | 1.72 |
| NP_004680 | −47.7 | 2296 | RR[KR] | LLL | 5.6 | 23 | 8.2 | 1.57 |
| NP_002244 | 1179 | 1981 | [HQN]Q[HQN] | LLL | 0.6 | 30 | 6.7 | 1.55 |
| NP_002960 | 297.7 | 2304 | [ED]D[ED] | LLL | 5.4 | 14 | 20.5 | 1.55 |
| NP_000689 | −36.3 | 2377 | [KR]D[GTSWYP] | ELL | 1 | 25 | 8.6 | 1.5 |
| NP_005875 | 258.7 | 2345 | RR[KR] | LLL | 6.8 | 13 | 12.6 | 1.5 |
| NP_114098 | −10.7 | 2370 | [ED]D[ED] | LLL | 3 | 20 | 8.9 | 1.49 |
| NP_036428 | −14.7 | 2471 | G[GTSWYP]F | LLL | 2 | 18 | 4.8 | 1.48 |
| NP_066189 | 237.7 | 2526 | [GTSWYP]E[IVL] | LLE | 0.7 | 9 | 1.1 | 1.48 |
| NP_000869 | −4.7 | 2251 | RR[KR] | LLL | 7.2 | 26 | 11.7 | 1.44 |
| NP_005222 | −22.3 | 2246 | [ED]D[ED] | LLL | 3.6 | 21 | 7.9 | 1.42 |
| NP_055413 | −20.7 | 2313 | [KR]D[GTSWYP] | ELL | 1.1 | 8 | 0.6 | 1.42 |
| NP_065795 | −33.3 | 2166 | RR[KR] | LLL | 7.8 | 18 | 6.1 | 1.35 |
| NP_000732 | 106.7 | 1894 | [IVL]N[HQN] | LLL | 1.8 | 16 | 4.9 | 1.28 |
| NP_002637 | −144.7 | 186 | PPP[IVL] | LLLL | 32.6 | 31 | 40.8 | 1.27 |
| NP_000675 | 347.7 | 1831 | [ED]D[ED] | LLL | 4.2 | 10 | 1.2 | 1.25 |
| NP_001773 | −28.7 | 1520 | [ED]N[IVL] | LLL | 3.7 | 13 | 22 | 1.23 |
| NP_003170 | −24.3 | 1300 | [ED]N[IVL] | LLL | 4.2 | 21 | 31.6 | 1.21 |
| NP_006454 | −18.7 | 1727 | [GTSWYP]K[ED] | HLL | 1.6 | 17 | 6.5 | 1.19 |
| NP_000013 | −26.7 | 1523 | [GTSWYP]E[KR] | LLE | 1.8 | 19 | 10.2 | 1.17 |
| NP_057627 | −28 | 1540 | [GTSWYP]S[IVL] | LLL | 1.2 | 13 | 4.2 | 1.12 |
| NP_689901 | 219.3 | 1436 | [GTSWYP]E[KR] | LLE | 1.9 | 17 | 8.9 | 1.1 |
| NP_004030 | −34.3 | 1448 | [GTSWYP]S[IVL] | LLL | 1.3 | 9 | 1.3 | 1.09 |
| NP_955359 | 376 | 1292 | [ED]D[ED] | LLL | 6.3 | 10 | 7.9 | 1.06 |
| NP_542417 | −207.7 | −4169 | [GTSWYP]RP[IVL]P | LLLLL | 82.4 | 26 | 110.2 | 1.03 |
| NP_002342 | 591 | 538 | [KR]D[GTSWYP] | ELL | 5.2 | 6 | 3.4 | 0.77 |