Table 3.
Distribution of Breakpoint Positions in Germ Cell Lines and in Cancer Cell Lines
Loci | Breakpoints | Samples | Number | Mean | Median | Mann-Whitney U test | Standard Deviation | Squared-Ranks Test | Skewness | Kurtosis |
---|---|---|---|---|---|---|---|---|---|---|
PARK2 | upstream breakpoints | patients with AR-JP | 162 | 162,632,436 | 162,648,608 | p = 0.36 | 203,951 | p < 0.0001 | −1.21 | 4.01 |
cancer cell lines | 32 | 162,549,884 | 162,626,524 | 401,285 | −0.30 | −0.37 | ||||
downstream breakpoints | patients with AR-JP | 162 | 162,462,592 | 162,515,588 | p = 0.53 | 210,775 | p < 0.0001 | −1.35 | 3.03 | |
cancer cell lines | 32 | 162,405,816 | 162,440,014 | 389,800 | −0.38 | −0.56 | ||||
DMD | upstream breakpoints | patients with DMD/BMD | 197 | 32,151,340 | 31,967,332 | p = 0.49 | 405,283 | p = 0.99 | 0.73 | −0.93 |
cancer cell lines | 6 | 32,063,805 | 31,932,249 | 518,968 | 1.57 | 2.75 | ||||
downstream breakpoints | patients with DMD/BMD | 197 | 31,969,561 | 31,796,456 | p = 0.78 | 402,560 | p = 0.81 | 0.80 | −0.71 | |
cancer cell lines | 6 | 31,900,988 | 31,816,981 | 600,593 | 1.12 | 2.25 |