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Molecular Modeling of Mitochondrial Class I Release Factor Proteins
The best fit for the predicted 3D structure of C12orf65, Ict1, mtRF1, or mtRF1a/mtRF1L is the crystal structure of translation release factor RF2 from E. coli (yellow). The red arrows indicate the conserved class I release factor motif GGQ in domain III. The yellow arrows indicate the domain II loop in which the tripeptide motif (SPF in RF2) involved in stop codon recognition is positioned.
