Figure 4.

Interaction Model of Human YARS2 with tRNA

The model shows the crystal structure of the enzyme¹⁷ (without the S4-like C-terminal domain) on which one tRNA^Tyr molecule has been docked according to its location in the crystal structure of a bacterial tryosyl-tRNA synthetase and tRNA^Tyr complex.³¹ The two monomers are distinguished by dark- and light-green color with the first β strand encompassing residue 52 (p.F52L), shown as the mutant L52, highlighted in purple. Note the proximity of L52 with the accepting end of tRNA shown as orange.