An application of TLOCT for studying the basic tumor biology of PDT response,
demonstrating a series of OCT cross-sectional images of ovarian cancer acini
taken from a full 3D data set at time points following BPD-PDT. (A) Ovarian
cancer acini appeared as small, solid and spherical structures immediately
following treatment (B). Twelve hours post-PDT, signs of structural
breakdown were seen (C). One day after PDT, the acini showed large-scale
structural deformation with the appearance of apoptotic cell clusters at the
nodules’ periphery. Few structural differences can be seen between
24 and 48 hours (D) following treatment. Reproduced with permission from ref
301. Copyright 2010, SPIE.