Production of angiogenic growth factors by MG63 cells on tissue culture polystyrene and Ti surfaces: (A) VEGF-A, (B) FGF-2, (C) EGF, and (D) Ang-1 levels were determined in the conditioned medium by ELISA. Cells were cultured on control (TCPS), PT, SLA, and modSLA Ti surfaces. Values presented are mean ± SEM of six independent cultures. The data presented are from one of two separate experiments with comparable results. Data were analyzed using ANOVA and statistical significance between groups was determined using Bonferroni's modification of Student's t-test. *p< 0.05, vs. TCPS; ·p<0.05, vs. PT; Φp<0.05, vs. SLA.