Table 1.

Spleen cell proliferation to VP4 in immunized mice^a.

Antigen dose (μg/mL)	pNZ8112b	pNZ8112-VP4c
0.5	0.036d ± 0.002	0.087d ± 0.003
5.0	0.058d ± 0.001	0.971d ± 0.003
Positive control (5 μg/mL Con A)	0.871 ± 0.003	0.822 ± 0.002
Control group (RPMI 1640)	0.031 ± 0.002	0.026 ± 0.002

^a n = 10.

^bSpleen cell proliferation from mice immunized with L. lactis harboring the pNZ8112 plasmid.

^cSpleen cell proliferation from mice immunized with L. lactis harboring the pNZ8112-VP4 plasmid.

^d P < .05 versus control (t-test).