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. Author manuscript; available in PMC: 2011 Jun 3.
Published in final edited form as: J Phys Chem B. 2010 Jun 3;114(21):7413–7422. doi: 10.1021/jp102092m

Table 3.

Ratio between the populations of conformationsa found for the α-tetrasubstituted α-amino acids in the G2, G3, and F4 mutants and the corresponding proteinogenic residues in wild-type Met-enkephalin.

αD εD γD δD βDL δL γL εL αL
Aib2 (G2) 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Aib3 (G3) 1.0 0.6 2.2 0.0 0.0 0.0 0.0 0.0 0.0
(2R,3R)c3diPhe4 (F4) –b –b –b 0.0 0.0 0.0 4.5 0.2 2.4
a

The nine types of backbone conformation defined in ref. 14 have been considered.

b

This conformation was not adopted by the α-tetrasubstituted residue.