Table 2.
Summary of association studies of IL-10 promoter polymorphisms with SLE.
| Reference | Population | SLE/controls | Polymorphisms | Associations |
|---|---|---|---|---|
| Rosado et al. (2008) [59] | Spanish | 116/51 | IL10G, IL10R −1082/−819/−592 |
No association of microsatellites Increased GCC in SLE |
| Guarnizo-Zuccardi et al. (2007) [31] | Colombian | 120/102 | −1082/−819/−592 | No association |
| Chen et al. (2006) [60] | Taiwanese | 237/304 | IL10G | Increased G9 and decreased G8 in SLE. G13 associated with anticardiolipin IgM antibodies and G8 with neurologic affectation. |
| Sung et al. (2006) [61] | Korean | 350/330 | −592 | No association with susceptibility −592C associated with SLE activity |
| Nath et al. (2005) [62] | Meta-analysis | 2391/3483 | IL10G/IL10R −1082/−819/−592 |
Increased G11 in whole population Increased −1082G in Asian populations |
| Khoa et al. (2005) [63] | Vietnamese | 64/57 | −1082 | Increased −1082G in SLE |
| Chong et al. (2004) [29] | Chinese | 550/689 554/708 |
IL10G, IL10R −1082/−819/−592 |
Increased G4 in SLE Increased −592CC in SLE |
| Schotte et al. (2004) [65] | German | 210/158 | IL10G, IL10R | No association with susceptibility R2-G14 associated with anti-Sm antibodies |
| Suarez et al. (2004) [45] | Spanish | 248/343 | −1082, −819, −592 | No association with susceptibility. Association of −1082G with discoid lesions |
| Dijstelbloem et al. (2002) [64] | Caucasian | 180/163 | −1082 | No association |
| D'Alfonso et al. (2002) [66] | Italian | 217/173 | −1082/−851/−592 IL10G |
Association of IL10G “long alleles” with SLE |
| D'Alfonso et al. (2000) [30] | Italian | 159/164 | IL10G, IL10R | Increased G11 and decreased G9 in SLE |
| van der Linden et al. (2000) [67] | Mixed | 44/125 | −1082/−851/−592 | No association |
| Alarcon-Riquelme et al. (1999) [68] | Mexican | 330/368 | IL10G | No association |
| Rood et al. (1999) [28] | Dutch | 92/162 | −1082/−819/−592 | Increased ATA in neuropsychiatric SLE |
| Crawley et al. (1999) [69] | Anglo-saxon | 120/274 | −1082/−819/−592 | No association |
| Mok et al. (1998) [34] | Chinese | 83/88 | −1082/−819/−592 | No association with susceptibility Increased ATA in renal disease |
| Mehrian et al. (1998) [70] | Mexican-American | 158/220 | IL10G | Increased G10 and decreased G9 in SLE |
| Eskdale et al. (1997) [71] | Anglo-Saxon | 56/102 | IL-10G, IL-10R | Increased G13 and decreased G9 in SLE |
| Lazarus et al. (1997) [27] | Anglo-Saxon | 76/199 | −1082/−819/−592 | GCC associated with anti-SSa |