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. Author manuscript; available in PMC: 2010 Jul 5.
Published in final edited form as: Biochemistry. 2005 Feb 8;44(5):1550–1560. doi: 10.1021/bi048089z

Figure 5.

Figure 5

Locations of the four newly identified activating sites, and of the four adaptation sites. The helices of subunit I are colored yellow and pink, and the helices of subunit II are colored blue and white. Adaptation sites are denoted in red and boxed. Positions where charge-neutralizing substitutions activate or have no effect on kinase activity are colored red or black, respectively. (B) Alternate view obtained by rotating the subdomain 90° about its long axis. Structures were generated with MacPymol (DeLano Scientific).