Figure-6.
(A and B) 17β-Estradiol prevents hemorrhagic shock induced ROS formation in rat mesentery. The images shown are of mesenteric post-capillary venules of sham, hemorrhagic shock for 1 hour MAP 40 mm Hg followed by 60 minutes of resuscitation and estradiol treatment 10 minutes prior to hemorrhagic shock (17β-estradiol + Shock) are shown. Increased ROS formation is observed following hemorrhagic shock whereas 173-estradiol treatment decreased the ROS formation. (B) ROS formation is expressed based on the changes in fluorescent intensity. Hemorrhagic shock induces ROS formation compared to sham-control group. 17β-Estradiol treatment prevents HS-induced ROS formation compared with hemorrhagic shock group without 17β-estradiol. * Significant difference vs. sham group (p <0.05). Significant difference vs. shock group (p <0.05).