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. Author manuscript; available in PMC: 2011 Apr 29.
Published in final edited form as: Neuron. 2010 Apr 29;66(2):248–259. doi: 10.1016/j.neuron.2010.03.021

Figure 4.

Figure 4

Endocannabinoid signaling mediates the effects of visual experience on iLTD. Systemic injection of CB1R agonist (WIN: 5mg/kg, i.p., twice a day for 3 days) prevents preservation of iLTD (A) and the TBS-induced decrease in PPD (B) typically seen in 5 week-old rats dark-reared for 2 weeks. Open circles: vehicle-injected controls; filled circles: WIN-injected. Systemic injection of the CB1R antagonist AM251 (5mg/kg, i.p., twice a day for 3 days) prevents the loss of iLTD (C) and the reduction in paired pulse depression (D) caused by light exposure for 2 days in 5 week-old rats dark-reared for 2 week). The rearing condition is depicted on the top of A and C. Example traces in B and D are averages of 10 responses recorded before (thin trace) and 30 min after TBS (thick trace). The asterisks denotes p<0.05 (t-test). In parentheses in A and C are the numbers of rats and cells.