Table 5.
Frequencies, Odds Ratios and 95% Confidence Intervals for First and Second/Third Trimester Pregnancy Loss According to PCE Exposure
| Number of Losses | Number of Livebirths | Crude Odds Ratio (95% CI) | Multivariatea GEE Odds Ratio (95% CI) | |
|---|---|---|---|---|
| First Trimester Losses | ||||
| Cumulative PCE Exposure up to LMP (g) | ||||
| >= 75th pctile | 56 | 529 | 1.0 (0.7–1.3) | 1.0 (0.7–1.4) |
| 50th – < 75th pctile | 51 | 530 | 0.9 (0.6–1.2) | 0.8 (0.6–1.3) |
| 25th – < 50th pctile | 48 | 531 | 0.8 (0.6–1.2) | 0.8 (0.5–1.2) |
| >0 – < 25th pctile | 66 | 522 | 1.2 (0.9–1.6) | 1.2 (0.8–1.7) |
| 0 (Referent) | 299 | 2796 | 1.0 (----) | 1.0 (----) |
| Maximum Annual PCE Before LMP Year (g) | ||||
| >= 75th pctile | 50 | 449 | 1.1 (0.8–1.5) | 1.1 (0.8–1.6) |
| 50th – < 75th pctile | 54 | 450 | 1.2 (0.9–1.6) | 1.2 (0.9–1.8) |
| 25th – < 50th pctile | 34 | 454 | 0.7 (0.5–1.1) | 0.6 (0.4–1.0) |
| >0 – < 25th pctile | 63 | 437 | 1.4 (1.0–1.9) | 1.6 (1.1–2.2) |
| 0 (Referent) | 319 | 3118 | 1.0 (----) | 1.0 (----) |
| Average Monthly PCE Exposure During LMP Year (g) | ||||
| >= 75th pctile | 38 | 443 | 0.8 (0.5–1.1) | 0.7 (0.5–1.1) |
| 50th – < 75th pctile | 34 | 441 | 0.7 (0.5–1.0) | 0.8 (0.5–1.2) |
| 25th – < 50th pctile | 41 | 436 | 0.9 (0.6–1.2) | 0.8 (0.5–1.2) |
| >0 – <25th pctile | 57 | 423 | 1.2 (0.9–1.6) | 1.3 (0.9–1.9) |
| 0 (Referent) | 350 | 3165 | 1.0 (----) | 1.0 (----) |
| Second/Third Trimester Losses | ||||
| Cumulative PCE Exposure up to LMP (g) | ||||
| >= 75th pctile | 14 | 529 | 1.0 (0.5–1.7) | 0.8 (0.4–1.7) |
| 50th – < 75th pctile | 18 | 530 | 1.2 (0.7–2.1) | 0.8 (0.4–1.7) |
| 25th – < 50th pctile | 20 | 531 | 1.4 (0.8–2.3) | 1.3 (0.7–2.2) |
| >0 – < 25th pctile | 10 | 522 | 0.7 (0.4–1.4) | 0.7 (0.4–1.5) |
| 0 (Referent) | 77 | 2796 | 1.0 (----) | 1.0 (----) |
| Maximum Annual PCE Before LMP Year (g) | ||||
| >= 75th pctile | 13 | 449 | 1.1 (0.6–2.0) | 1.0 (0.5–2.1) |
| 50th – < 75th pctile | 13 | 450 | 1.1 (0.6–2.0) | 0.9 (0.4–1.9) |
| 25th – < 50th pctile | 19 | 454 | 1.6 (0.9–2.6) | 1.3 (0.7–2.3) |
| >0 – < 25th pctile | 11 | 437 | 0.9 (0.5–1.8) | 1.0 (0.5–1.9) |
| 0 (Referent) | 83 | 3118 | 1.0 (----) | 1.0 (----) |
| Average Monthly PCE Exposure During LMP Year (g) | ||||
| >= 75th pctile | 8 | 443 | 0.6 (0.3–1.2) | 0.6 (0.2–1.3) |
| 50th – < 75th pctile | 14 | 441 | 1.0 (0.6–1.8) | 1.0 (0.5–1.9) |
| 25th – < 50th pctile | 12 | 436 | 0.9 (0.5–1.7) | 0.6 (0.3–1.5) |
| >0 – < 25th pctile | 9 | 423 | 0.7 (0.4–1.4) | 0.7 (0.3–1.4) |
| 0 (Referent) | 96 | 3165 | 1.0 (----) | 1.0 (----) |
a
Controlled for maternal age, paternal age, maternal history of gynecologic infections, number of prior livebirths, and year of pregnancy