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. 2010 Jun 11;11(7):522–527. doi: 10.1038/embor.2010.81

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Copyright © 2010, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial No Derivative Works 3.0 Unported License, which permits distribution and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.

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Coupled coordination of the two sulphate ion ligands. (A) Difference density for the sulphate ions. Difference density ((∣F_o∣−∣F_c∣)e(iα_c)) is contoured at 3.0 sigma values over the mean, where ∣F_o∣ is the observed structure factor amplitudes and ∣F_c∣ and α_c are structure factor amplitudes and phases calculated from a model prior to including the sulphates. (B) Potential hydrogen bonds of the two sulphate ions (I and II) to side-chain and main-chain atoms of the Nc QDE-2 MID domain. Relevant side chains and the main chain of strand β4 are shown as sticks. Hydrogen bonds are shown as dotted lines. Asp 603 (pink) corresponds to the aspartate proposed by Djuranovic et al (2010) to effect allosteric regulation of miRNA binding. Red: oxygen; blue: nitrogen; yellow: sulphur. MID, middle; miRNA, micro RNA; Nc, Neurospora crassa; QDE-2, quelling deficient 2.