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. Author manuscript; available in PMC: 2010 Jul 29.
Published in final edited form as: Science. 2009 Dec 17;327(5965):593–596. doi: 10.1126/science.1166202

Fig. 1.

Fig. 1

Deletion of the intrinsic pathway of apoptosis in the hematopoietic system protects mice from death after whole-body gamma irradiation (WBI). A. Western blot for BAX and tubulin in spleen, lymph node, and thymus from Tie2Cre; Bak1−/−; BaxFL/− mice (FL/−) demonstrates deletion of Bax in the hematopoietic system. Tie2Cre; Bak1−/−; BaxFL/+ mice (FL/+) retain Bax and serve as a control. B. Kaplan-Meier survival analysis of Tie2Cre; Bak1−/−; BaxFL/+ mice and Tie2Cre; Bak1−/−; BaxFL/− litter mates after 12.5 Gy WBI. By log-rank comparison, p = 0.0001.