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. Author manuscript; available in PMC: 2010 Jul 6.
Published in final edited form as: Pharm Res. 2008 May 1;25(7):1730–1734. doi: 10.1007/s11095-008-9592-5

FIGURE 3.

FIGURE 3

Kinetic analysis of CBR1 inhibition by increasing concentrations of monoHER in the presence of the substrates daunorubicin (panel A), and menadione (panel B). Each point represents the mean ± S.D. of two experiments performed in duplicate with two independent protein preparations. Insets: graphical determination of Ki values. Replot of the slopes from double-reciprocal plots (panel A; r2>0.90), and replot of the 1/velocity y-intercepts from double reciprocal plots (panel B; r2>0.90). Similar Ki values were obtained from non-linear regression analyses (see text).