Figure 1.

Platelet product quality and product safety determine the restriction of the platelet shelf-life. Platelet storage lesion and risk of pathogen contamination are the main targets for investigation towards prolongation of the shelf-life. Proteomics provides an excellent tool to address these issues in order to identify protein targets for intervention. Subsequent development of PAS and improvement of PRT will lead to the deceleration of PSL progression as well as a reduction in PRT-mediated effects in platelet concentrates. This synergy will hopefully achieve reduced PSL development while maintaining pathogen risk reduction towards a potential increase in the shelf-life of platelet concentrates.