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. Author manuscript; available in PMC: 2011 Jul 20.
Published in final edited form as: Virology. 2010 May 6;403(1):85–91. doi: 10.1016/j.virol.2010.03.038

Figure 1.

Figure 1

Location of BC loop (residues 329-333, in cyan) in the WNV E domain III: (a) lateral view of domain III, oriented as for the complete E protein structure (inset); (b) rotated 30° to the left to show the location of Y329 (in yellow). (c) Amino acid sequence alignment of flavivirus domain III residues equivalent to 302-337 of WNV; flavivirus-conserved cysteines and BC loop residues 329-333 are boxed. Mammalian tick-borne flaviviruses are ordered according to their proximity to the root of that branch in previous phylogenetic analyses of their evolution (Gaunt et al., 2001; Grard et al., 2007) showing replacement of tyrosine with phenylalanine and shortening of the BC loop.